精神疾患は体の病気と違って、病態を示す生物学的指標が必ずしも明確ではないので、疫学的な指標、例えば罹患率（発症の頻度）とか有病率（病気の割合）がはっきりしていない部分があります。このため、精神疾患の疫学研究はとても重要です。特に自閉症や注意欠如多動性障害（ADHD）などの発達障害は、治療はもちろん、その原因や予防も含めてまだ多くのことが分かっていません。精神保健の立場からこのような精神疾患の原因と予防法を探ります。

精神医学は患者さんを治療する臨床医学の一部門ですが、社会精神医学という分野があるように、衛生学や公衆衛生学などの社会医学と深く関係しています。社会医学とは文字通り、その対象とする研究や臨床活動が社会と密接に関連している医学の分野です。精神医学で扱う疾患の中には、診断基準が社会の価値概念と強く結びついているものが多くあります。例えば異常性格を意味するパーソナリティ障害群の一つに反社会性パーソナリティ障害というのがありますが、犯罪行為など社会のルールに著しく反する行動などによって特徴付けられています。逆に慈善事業などの社会貢献活動に人並外れて熱心に取り組むような性格の人は異常性格とは呼ばれません。また、自閉症などの発達障害にしても、昨今は成人期、特に職場において大きな問題となっていますが、単に仕事の要領が悪かったり、コミュニケーションが苦手だったりするだけで、短絡的に発達障害というレッテルを貼られてしまうこともあり、過剰診断が問題となっています。学生の皆さんとこのような精神医学と社会の関係について考えていきたいと思います。

• 研究主題

  発達障害に対する遺伝要因と環境要因の交互作用

  精神疾患全般の疫学研究

  精神保健における多職種連携

  成人期の発達障害

  発達障害と薬物依存・乱用の関連性

  認知症と介護負担

  振動工具取扱者の労働災害

• 研究業績（2014年以降）

  著書

   

  Kiyohara C, Yoshimasu K:

        Lung cancer and smoking behavior.

  Encyclopedia of Cancer, 4th Edition,

        Schwab M ed, pp2088-2094, Springer-Verlag, New York, 2015

   

  吉益光一：

  　　　自殺の予防.

        今日の治療指針2019年版, 1061-1062頁，医学書院，東京, 2019

   

   

  総説

   

  Yoshimasu K, Kiyohara C, Takemura S, Nakai K:

        A meta-analysis of the evidence on the impact of prenatal and early infancy

  exposures to mercury on autism and attention deficit/hyperactivity disorder in

  the childhood.　

  NeuroToxicology 44: 121-131, 2014

   

  Yoshimasu K:

  　　　Substance-related and addictive disorders as a risk factor of suicide and

  homicide among patients with ADHD: a mini review.

  Curr Drug Abuse Rev 9(2):80-86,2016

   

  宮下和久，前田節雄，竹村重輝，津野香奈美，吉益光一:

  　　　近年の振動障害研究の国際動向．

  産業医学レビュー  27(3):189-218，2014

   

  吉益光一, 藤枝恵, 原田小夜, 井上眞人, 池田和功, 嘉数直樹, 小島光洋, 山田全啓, 窪山泉:

        精神科救急医療体制の現状と課題：日本公衆衛生学会モニタリング・レポート委員会精神保健福祉分野活動総括（特別論文）. 日本公衆衛生雑誌　66（9）：547-559, 2019

   

  原著

   

  Takemura S, Yoshimasu K, Fukumoto J, Mure K, Nishio N, Kishida K, Yano F, Mitani T,

  Takeshita T, Miyashita K:

   　　 Safety and adherence of Umezu Polyphenols in the Japanese Plum (Prunus mume) in a 12-week double-blind randomized placebo-controlled pilot trial to evaluate antihypertensive effects.

  Environ Health Prev Med 19：444-451, 2014

   

  Kondo T, Yoshimasu K, Tokunaga S, Sugahara H, Kanemitsu Y, Kubo C:

  Age-related changes in visceral patterns associated with anxiety disorders or

  depression according to traditional Chinese Medicine.

  Integr Med Int 1: 80–92, 2014

   

   

  Kondo T Tokunaga S, Sugahara H, Yoshimasu K, Kanemitsu Y, Kubo C:

  Identification of visceral patterns in patients with stress-related disorders.

  Integr Med Int 1:185–198, 2014

   

   

  Yokoi K, Yoshimasu K, Takemura S, Fukumoto J, Kurasawa S, Miyashita K:

   Short stick exercises for fall prevention among older adults: a cluster

  randomized trial. Disabil Rehabil 37(14):1268-1276, 2015

   

   

  Yoshimasu K, Mure K, Hashimoto M, Takemura S, Tsuno K, Hayashida M, Kinoshita K,

  Takeshita T, Miyashita K:

   Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms as

  indicator of mental disorders in Japanese employees.

  Alcohol Alcohol 50(1):39-45, 2015

   

   

  Tomura T, Yoshimasu K, Sakaguchi S, Tsuno K, Takemura S, Miyai N, Miyashita K:

  Influence of biomedical factors on the Five Viscera Score (FVS) on middle-aged and elderly individuals: application of structural equation modeling.

  Evid Based Compl Alt Med　501:687015，2015

   

   

  Kurasawa S, Yokoi K, Miyai N, Yoshimasu K, Takemura S, Miyashita K:

  Assessment of the exercise intensity of short stick exercises in elderly

  individuals.

  Rehabil Res Pract 2015:209368, 2015

   

   

  Yoshimasu K, Mure K, Hashimoto M, Takemura S, Tsuno K, Hayashida M, Kinoshita K, Takeshita T, Miyashita K:

  Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is

  strongly associated with depression and anxiety in Japanese employees.

  Drug Alcohol Depend 147:130-136, 2015

   

  Takemura S, Yoshimasu K, Tsuno K, Fukumoto J, Kuroda M, Miyashita K:

  Associations between anthropometric factors and peripheral neuropathy defined by vibrotactile perception threshold among industrial vibrating tool operators

  in Japan.

  J Occup Health 58(2):145-154,2016

   

   

  Su AT, Maeda S, Fukumoto J, Miyai N, Takemura S, Awang B, Yoshimasu K, Miyashita K:

  A proposal on neurological dose-response relationship for inclusion in ISO 5349-1 documentation to be used in tropical environment.

  Acoustics Australia 44(2): 379-382, 2016

   

   

  Eskin M, Sun JM, Abuidhail J, Yoshimasu K, Kujan O, Janghorbani M, Flood C, Carta MG, Tran US, Mechri A, Hamdan M, Poyrazli S, Aidoudi K, Bakhshi S, Harlak H,

  Moro MF, Nawafleh H, Phillips L, Shaheen A, Taifour S, Tsuno K, Voracek M:

   　　 Suicidal behavior and psychological distress in university students:

  A 12-nation study.

  Arch Suicide Res 20(3):369-388, 2016

   

   

  Eskin M, Kujan O, Voracek M, Shaheen A, Carta MG, Sun JM, Flood C, Poyrazli S, Janghorbani M, Yoshimasu K, Mechri A, Khader Y, Aidoudi K, Bakhshi S, Harlak H,

  Ahmead M, Moro MF, Nawafleh H, Phillips L, Abuderman A, Tran US, Tsuno K:

  Cross-national comparisons of attitudes towards suicide and suicidal persons in university students from 12 countries.

  Scand J Psychol 57(6):554-563, 2016

   

   

  Yoshimasu K, Barbaresi WJ, Colligan RC, Voigt RG, Weaver AL, Katusic SK:

  Mediating and moderating role of depression, conduct disorder or

  attention-deficit/hyperactivity disorder in developing adolescent substance use disorders: a population-based study.

  PLoS One 11(6):e0157488, 2016

   

   

  Yoshimasu K, Barbaresi WJ, Colligan RC, Voigt RG, Killian JM, Weaver AL, Katusic SK:

  Adults with persistent ADHD: gender and psychiatric comorbidities-a population-based longitudinal study.

  J Atten Disord. pii: 1087054716676342, 2016

   

  Oga H, Yoshimasu K:

  A pilot study of self-care program of mindful life approach for improvements of socially problematic behaviors of children with developmental disorders through caregivers.

  J Psychol Psychother 6: 245. doi:10.4172/2161-0487.1000245, 2016

   

   

  Yoshimasu K, Takemura S, Tsuno K, Hayashida M, Kinoshita K, Mure K, Takeshita T,

  Miyashita K:

  Depression, alcoholism, and genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms among Japanese community-dwelling adults.

  Arch Depress Anxiety, 2(1):37-43, 2016

   

   

  Katusic SK, Colligan RC, Myers SM, Voigt RG, Yoshimasu K, Stoeckel RE, Weaver AL:

  What can large population-based birth cohort study ask about past, present and future of children with disorders of development, learning and behaviour?

  J Epidemiol Community Health 71(4):410-416, 2017

   

   

  Yoshimasu K, Barbaresi WJ, Colligan RC, Voigt RG, Killian JM, Weaver AL, Katusic SK: Psychiatric comorbidities modify the association between childhood ADHD and

  risk for suicidality: a population-based longitudinal study.

  J Atten Disord, doi: 10.1177/1087054717718264, 2017

   

   

  Kondo T, Tokunaga S, Sugahara H, Yoshimasu K, Akamine M, Kanemitsu Y, Fujisawa K,

  Masuda Y, Kubo C:

  Are five viscera involved in anxiety and depression?

  Int J Complement Alt Med 6(2): 00180, 2017

   

   

  Saito S, Kawabata T, Tatsuta N, Kimura F, Miyazawa T, Mizuno S, Nishigori H, Arima T,Kagawa Y, Yoshimasu K, Tsuno K, Ito Y, Kamijima M, Nakai K, Yaegashi N, Miyagi Study Group of Japan Environment & Children’s Study:

  Determinants of polyunsaturated fatty acid concentrations in erythrocytes of

  pregnant Japanese women from a birth cohort study: study protocol and baseline findings of an adjunct study of the Japan environment & Children’s study.

  Environ Health Prev Med 22:22, doi: 10.1186/s12199-017-0636-5, 2017

   

   

  Eskin M, Poyrazli S, Janghorbani M, Carta MG, Tran US, Mechri A, Hamdan M, Nawafleh H, Sun JM, Flood C, Yoshimasu K, Kujan O, Aidoudi K, Bakhshi S, Harlak1 H, Moro MF, Khader Y, Phillips L, Shaheen A, Taifour S, Tsuno K, Voracek M:

  The role of religion on suicidal behavior, attitudes and psychological distress in university students: a multinational study.

  Transcultural Psychiatry doi: 10.1177/1363461518823933. [Epub ahead of print]

   

   

  Yoshimasu K, Sato A, Miyauchi N, Tsuno K, Nishigori H, Nakai K, Arima T, Japan

  Environment & Children’s Study Group:

  Lack of association between receiving assisted reproductive technologies

  treatment and parental psychological distress during pregnancy: Preliminary

  findings of the Japan Environment and Children’s Study.

  Reprod Biomed Soc Online 5:5-16, 2018

   

   

  Kitano N, Yoshimasu K, Yamamoto BA, Nakamura Y:

        Associations between childhood experiences of parental corporal punishment and neglectful parenting and undergraduate students' endorsement of corporal

  punishment as an acceptable parenting strategy.

        PLoS One 13(10):e0206243, 2018

   

   

  Ito Y, Ueyama J, Nakayama SF, Isobe T, Oya N, Sato H, Ebara T, Yoshimasu K, Tsuno K, Tatsuta N, Nakai K, Kamijima M:

        Within-individual and interlaboratory variability analyses of urinary

  metabolites measurements of organophosphorus insecticides.

  J Expo Sci Environ Epidemiol (in press)

   

  Yoshimasu K, Miyauchi N, Sato A, Yaegashi N, Nakai K, Hattori H, Arima T; Japan

  Environment and Children's Study Group:

        Assisted reproductive technologies are slightly associated with maternal lack

  of affection toward the newborn: The Japan Environment and Children's Study.

        J Obstet Gynaecol Res (in press)